GlobeImmune, Inc.

we are a biopharmaceutical company established in 1995 focused on developing products for the treatment of cancer and infectious diseases based on our proprietary tarmogen ® platform. tarmogens activate the immune system by stimulating a subset of white blood cells called t cells that destroy infected or malignant cells, in contrast to traditional vaccines which predominately stimulate antibody production. we believe that our tarmogen platform has applicability to a number of diseases, and may enable us to develop a broad portfolio of products. we have four tarmogen product candidates in clinical evaluation for infectious disease and multiple cancer indications. tarmogens target the molecular profile that distinguishes a diseased cell from a normal cell. we have designed tarmogens to target specific intracellular and extracellular proteins, or antigens, that play a role in oncology and infectious diseases which represent unmet medical needs. collaborations with biopharmaceutical companies and research institutions have allowed us to advance the development of a number of our product candidates while managing our own research and development expenses relating to these product candidates. we have two strategic collaborations with leading biotechnology companies. in october 2011, gilead sciences, inc., exclusively licensed product candidates intended to treat chronic hepatitis b virus, or hbv, infection. celgene corporation entered into a collaboration and option agreement for certain oncology product candidates in may 2009. under this agreement, in july 2013 celgene exercised its option for a worldwide, exclusive license to the gi-6300 program, which is a tarmogen program targeting the brachyury protein. brachyury plays a role in the metastatic spread of certain cancers and is believed to be fundamental in the formation of chordomas, rare bone tumors of the spine. through june 30, 2014, we have received over $60 million from these collaborations.

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